Importantly, subsequent treatment of HUVEC, in which angiogenic signalling was induced by culture in human serum, with sunitinib and several other anti-angiogenic drugs counteracted tumor endothelial cell anergy, as exemplified by induction of endothelial ICAM-1 expression in vitro, both at the mRNA- and protein levels (Fig. 4b-c). The gene discussed is ICAM1; the disease is neoplasm.