It is intriguing that although both TRPV1 and TRPA1 mediate Ca2+ influx that initiates intracellular Ca2+ signaling in a similar manner, loss of function of TRPV1 and TRPA1 show opposite phenotypes in mouse models of experimental colitis (Bertin et al., 2014; Bertin et al., 2017). The gene discussed is TRPV1; the disease is colitis.