TFF2 and colitis: On the other hand, another study reported that capsaicin-induced denervation of the TRPV1+ extrinsic sensory fibers in neonatal mice exacerbates oxazolone-induced colitis without significant changes in the expression of CGRP+ or SP+ nerve fibers in the colon, suggesting a dispensable role of neuropeptides and the involvement of additional nociceptor-derived neurotransmitters in the pathogenesis of the colitis (Lee et al., 2012).