Pharmacological activation of TRPM8 by repeated applications of menthol enemas protects against DSS-induced colitis while global TRPM8 KO aggravates colitis severity, which is correlated with the profile of macrophage-derived TNFα (inflammatory) and interleukin-10 (anti-inflammatory) cytokine production (Khalil et al., 2016; Fig. 1). This evidence concerns the gene TRPM8 and colitis.