Although nociceptor-expressed TRPV1 is essential to the generation of inflammatory thermal pain (Julius, 2013), CD4+ T cells were also reported to express functional TRPV1 which was shown to play a pro-inflammatory role in a mouse model of colitis (Bertin et al., 2014), which is in marked contrast to TRPA1 activation of which was shown to attenuate colitis (Bertin et al., 2017). The gene discussed is TRPA1; the disease is colitis.