CHRNA7 and colitis: The α7nAChR protein is also markedly increased in the inflamed colon in a mouse model of DSS-induced colitis and demonstrates a protective role in DSS-induced inflammation as the α7nAChR agonist PNU282987 suppresses DSS-induced colon inflammation in vivo and reduces LPS-induced increase in cytokine production and ROS levels in α7nAChR-expressing macrophages in vitro (Xiao et al., 2020).