AOM/DSS-induced murine colorectal cancers frequently carry mutations in Ctnnb1 and Kras and chronic inflammation-related MSI (Sharp et al., 2018), the Wnt pathway is constitutively activated, closely mirroring human CRC at the molecular level (Schulz-Heddergott et al., 2018). The gene discussed is CTNNB1; the disease is colorectal cancer.