INS and congenital isolated hyperinsulinism: This causes closure of the KATP channels, leading to membrane depolarization, calcium influx through VDCCs, and triggering of insulin release.5,6 Congenital hyperinsulinism (CHI) is the most common cause of hypoglycemia in neonates and infants7 and is often linked to loss-of-function (LOF) mutations in KATP.