ABCC8 and Impaired glucose tolerance: In mice with such a marked loss of KATP channels, a common theme of early transient hyperinsulinemic hypoglycemia followed by normoglycemia or impaired glucose tolerance as adults has been described.16,18,19,31 A similar progression has also been seen in some humans with CHI due to KATP LOF.28,32,33 Preliminary measurements suggest that SUR1−/− larvae also have lower whole-body glucose compared to wildtype (not shown), but random fed blood glucose in both homo- and heterozygous fish was not different from WT (Figure 1c).