Recently, MIR100HG was reported to modulate the transforming growth factor beta (TGFβ) signaling pathway, the latter of which is subjugated by HPV in head and neck squamous cell carcinoma and induces epithelial-to-mesenchymal transition in keratinocytes transformed by HPV16 [61,62,63]. Here, MIR100HG is linked to head and neck squamous cell carcinoma.