Evidence suggests that SH3PXD2A-AS1 acts as an oncogene in colorectal cancer and esophageal squamous cell carcinoma, with SH3PXD2A-AS1 knockdown resulting in the inhibition of colorectal tumor growth and migration [42, 43, 44, 45]. The gene discussed is SH3PXD2A; the disease is esophageal squamous cell carcinoma.