ANXA11 and amyotrophic lateral sclerosis: Recent genetic studies from independent ALS cohorts revealed that variants in ANXA11 were responsible for both familial and sporadic ALS (sALS).16–18,20–23 These studies also demonstrated that several ALS patients carried ANXA11 variants clustered in specific regions (hotspots) in the N-terminal LCD, such as p.P36R, p.G38R and p.D40G/p.D40Y.