However, it was still possible to identify a higher incidence of bulbar-onset ALS patients in those with ANXA11 variants than in those without ANXA11 variants (Supplementary Table 3).36 In terms of the progression speed, a steeper deterioration rate in the early stage of the disease was detected in patients with LCD variants than in patients carrying ANX domain variants. Here, ANXA11 is linked to amyotrophic lateral sclerosis.