ANXA11 and amyotrophic lateral sclerosis: Further research on the Chinese and Taiwanese ALS patients identified three novel missense variants and one splicing variant detected in Japanese patients was reported as a post-mortem tissue neuropathologic finding.18,21,22 The same variant, p.D40Y, previously reported in French ALS patients, was also identified in the two Brazilian fALS patients.23 Our results are closer to those found in the Chinese patients with ALS.20 The frequency of ANXA11 variants in our data and the Chinese cohort was relatively higher than that of the European cohort.