Considering the low prevalence of ALS-FTD (4.8%) in our previous sALS cohort study, we regard this finding of numerous ALS-FTD patients carrying variants clustered in a specific region of a single gene as a highly significant discovery (Supplementary Table 3).35 In addition, patients with variants in the ANXA11 LCD tended to experience bulbar problems as the first symptom of ALS in contrast to patients carrying ANX domain variants, although there was no statistical significance. This evidence concerns the gene ANXA11 and frontotemporal dementia.