A previous study reported the old onset age (average, 67 years) of ALS patients carrying ANXA11 variants.16 All subjects included in the current study also showed a late age of onset (average, 64.2) compared with the average age of onset in the Korean ALS patients (average, 60.4; Supplementary Table 3).3 In patients with ANXA11 variants, the age of onset was significantly older in patients carrying LCD variants than in patients with ANX domain variants. This evidence concerns the gene ANXA11 and amyotrophic lateral sclerosis.