An explanation mechanism for the decrease of bone mineral density caused by antiseizure medication is that antiseizure medication induce the liver P-450 enzyme system, resulting in an increase in 25-hydroxyvitamin D catabolism, resulting in relatively hypocalcemia, an increase in parathyroid hormone level, and ultimately a decrease in bone mineral density (11, 34, 35). Here, CYP2B6 is linked to Hypocalcemia.