The time zone view can be analyzed from two periods: before 2005, there was little research in this field, which did not attract wide attention of researchers, so there were only a few hot keywords; since 2006, glucocorticoid receptor, DNA methylation, gene expression, brain development, epigenetic regulation, hypothalamic pituitary adrenal axis, depression, and posttraumatic stress disorder gradually emerged and achieved rapid development. Here, NR3C1 is linked to depressive disorder.