HSPA5 and neurodegenerative disease: Gómez-Almería et al. created mutant superoxide dismutase 1 (mSOD1) and Bip double mutant (mSOD1/Bip+/-) mice to study the role of Bip in a mouse model of the neurodegenerative disease ALS (Gómez-Almería et al., 2021).