INS and metabolic dysfunction-associated steatotic liver disease: Recent studies utilizing proteomic approaches have identified myriad signaling pathways that are disrupted by clinically relevant AA exposures in pre-clinical and clinical samples that are associated with significant changes in multiple NAFLD associated pathways including those regulating lipid metabolism, mitochondrial function, inflammation, iron metabolism and insulin signaling (May et al., 2019, 2020, 2022; Beauchemin et al., 2020; Rostama et al., 2020).