BRAF and colorectal cancer: The WAS/WASL interacting protein family member 1 (WIPF1) regulates actin, phagocytosis, and neurotransmission and is among the top-3 genes upregulated by caloric restriction in the hypothalamus of wild-type mice (70). Furthermore, overexpression of WIPF1, triggered by BRAF-mutation activated MAP kinase pathway, promotes aggressiveness of thyroid cancer and thus acts like an oncoprotein (71). Its oncoprotein character was also described for pancreatic adenocarcinoma (72) as well as breast cancer, glioma and colorectal cancer (73).