To assess whether the observed correlation between ISG induction and SRSF1 repression in the early immune response upon HIV-1 infection was induced by IFN signaling, the effect of IFNα subtypes (α1, α2, α4, α5, α6, α7, α10, α14, α16, α17, and α21) on the mRNA expression levels of ISG15 and SRSF1 was analyzed. The gene discussed is IFNA1; the disease is HIV-1 infection.