In our further studies, we included the subtypes IFNα2 and IFNα14 as IFNα14 was shown to be the most potent subtype against HIV-1 (27) and induced the strongest downregulation of SRSF1 mRNA levels (Figure 3B), while IFNα2 is the sole IFNα subtype currently in clinical use for the treatment of other viral infections such as HBV (28). Here, IFNA2 is linked to viral infectious disease.