For example, proinflammatory mediators of tumor cells such as the high mobility group box 1 (HMGB1) protein or the 70 kilodalton heat shock protein (HSP70) facilitate TAA processing and presentation, whereas plasma membrane components such as calreticulin or phosphatidylserine residues promote phagocytosis or TAA recognition, respectively (26). Here, HMGB1 is linked to neoplasm.