On the basis of our results, the TIS score exhibited an inverse association with effector killing cells, such as activated CD8 T cells and CD56 bright natural killer cells, whereas it was positively implicated with immunosuppressive cells, such as MDSC and regulatory T cells, indicating that patients with a higher TIS score are vulnerable to immunosuppression and attenuated tumor clearance. The gene discussed is NCAM1; the disease is neoplasm.