EGFR and colorectal carcinoma: To enhance EGFR CAR T-cell cytotoxicity, persistence, and to overcome a hostile TME in CRC, fourth-generation EGFR-IL12 CAR T-cells, also known as T-cells redirected for universal cytokines (TRUCKs), are engineered to secrete IL-12, a proinflammatory cytokine EGFR-IL12 TRUCKs express IL-12 upon activation and deliver it to enhance local antitumor immune responses, such as activating NK cells and repolarizing macrophages.