In contrast to classical target-specific CAR T-cells, NKR-2 recognizes various ligands on tumor cells and exhibits the potential to target several tumors (160). In addition to direct recognition of tumor cells, NKR2 is expected to target NKG2D-positive non-tumor cells within the stroma, tumor blood vessels, and immunosuppressive TME, which disrupts the support mechanisms essential for tumor cell survival and growth (161). Here, KLRK1 is linked to neoplasm.