To explore the expression patterns of m6A regulators between T1DM and healthy individuals, we detected the expression levels of 23 major regulators, including 10 writers (METTL3, METTL14, WTAP, RBM15, RBM15B, VIRMA/KIAA1429, METTL16, CBLL1/HAKAI, ZC3H13, and ZCCHC4), 2 erasers (FTO/ALKBH9 and ALKBH5) and 11 readers (YTHDF1, YTHDF2, YTHDF3, YTHDC1, YTHDC2, IGF2BP1, IGF2BP2, IGF2BP3, HNRNPA2B1, HNRNPC, and HNRNPG). Here, METTL16 is linked to type 1 diabetes mellitus.