Increased serum levels of resistin, leptin, and visfatin, as well as decreased expression of forkhead box P3 (FoxP3) mRNA in T cells,have been observed in MS patients, correlating with circulating levels of TNF-α, and IL-1β (95), as well as with disability progression (96), indicating resistin could be an important driver of chronic inflammation. This evidence concerns the gene RETN and myeloid sarcoma.