-In RRMS patient serum and CSF, levels are increased in correlation with increased IFN-≤ levels, and reduction of Treg cells.-Serum leptin levels and EDSS correlate positively in SPMS and PPMS-Although some controversies persist, the general trend in the data points toward increased levels of leptin in MS, associated with increased disease burden- The age of onset and sex conditions differences in leptin levels. The gene discussed is LEP; the disease is relapsing-remitting multiple sclerosis.