C-reactive protein (CAR), which combines CRP and ALB, has become an effective indicator for evaluating the prognosis of various diseases in recent years, including acute coronary syndrome (31), various cancers (hepatocellular carcinoma, gastric cancer, ovarian cancer) (32), and various inflammatory diseases (rheumatoid arthritis, Crohn's disease) (14). This evidence concerns the gene CRP and rheumatoid arthritis.