Four-repeat tauopathies such as corticobasal degeneration might be plausible, based on the asymmetric distribution patterns on tau PET imaging, despite not presenting with a typical corticobasal degeneration or progressive supranuclear palsy pattern (22), since pyramidal/extrapyramidal symptoms can appear after cognitive decline (38). This evidence concerns the gene MAPT and Classical progressive supranuclear palsy.