BCHE and early-onset autosomal dominant Alzheimer disease: In the Chinese Guidelines for the Diagnosis and Treatment of Alzheimer's Disease published in 2020 (4), there are mainly two types of drugs approved to alleviate cognitive impairment in AD patients, including cholinesterase inhibitors (donepezil, rivastigmine, and galantamine) and glutamate receptor antagonists (memantine), as well as drugs to treat psychiatric symptoms in AD patients.