An experimental study in a rat sepsis model has reported the renal protection capacity of EPP-AF® as an antioxidant and as an anti-inflammatory molecule due to its ability to reduce the expression of toll-like receptor 4 (TLR-4) and nuclear factor-kappa B (NF-kB) as well as cytokines in the renal tissue [11]. This evidence concerns the gene TLR4 and Sepsis.