Once the IL1 receptor complex is formed, they are able to activate a downstream signaling cascade which stimulates different immune responses and inflammatory genes (Jensen, 2017). A lot of studies suggest that inflammatory and angiogenic cytokines including IL1 contribute to KS pathogenesis through inducing abnormal proliferation, angiogenesis, as well as a KS-like phenotype (Ensoli et al., 1992). Here, IL1A is linked to Kaposi's sarcoma.