In the current study, we found that many of IL1 signaling molecules (e.g., IL1α, IL1β, IL1R1, IL1RAP, IL36, IL36R and IRAKs) were highly activated during KSHV infection or in KSHV+ tumor cells and tissues, indicating the crucial role of these molecules functions in KSHV pathogenesis and oncogenesis. Here, IL1RL2 is linked to neoplasm.