After screening of the major ligands and receptors/co-receptors in the IL1 signaling, we found that compared to BL-41, a KSHV negative lymphoma cell line, KSHV+ PEL cell lines such as BCBL-1 displayed elevated levels of many IL1 signaling molecules, some of which having dramatically increasing, especially IL1β, IL1R1, IL1RAP, IL36α, IL36γ and IL36R, while the others not changed or undetectable such as IL1α, IL33, using RT-qPCR (Figure 1A). This evidence concerns the gene IL1RAP and lymphoma.