UCP1 and endothelial dysfunction: Interestingly, we observed that aP2-DKO exhibited slightly impaired endothelium-dependent vasodilation in physiological condition, and showed more severe endothelial dysfunction compared with UCP1-DKO mice in HFD condition, but we did no find more severe vascular remodeling and higher BP in aP2-DKO compared with UCP1-DKO mice in pathological condition.