Baelde et al. found a decline in Vegfa expression in renal biopsies of patients with DN compared with control kidneys (native kidneys with normal histology and function, cadaver donor kidneys unfit for transplantation because of technical reasons, and the unaffected part of tumor nephrectomy samples); moreover, there was a relationship between the decrease in glomerular Vegfa levels and the amount of interstitial fibrosis (Baelde et al., 2007). The gene discussed is VEGFA; the disease is liver dysplastic nodule.