CD4 and autoimmune disease: Fichna et al. (Fichna et al., 2021) suggested that miR-7977 is increased in CD4+T cells of autoimmune Eddie’s disease patients and plays a crucial function in autoimmune diseases; Horiguchi et al. (Horiguchi et al., 2016) found that miR-7977 can reduce the hematopoietic support ability of bone marrow CD34+ cells.