ITGB2 and hyperinsulinemic hypoglycemia, familial, 4: Also, we confirmed this conclusion via qPCR and found that inhibitory effect in inflammasome associated genes (NAIP5, NLRC4, TXK, and NAIP6) and genes related to integrin pathway (ITGB2, ITGAM, ITGB2L, and ITGAL) after p16 deficiency (Figure S4(a)).