As shown in Figure 1(a), 22 DEPGs (including AIM2, CASP1, CASP5, CASP6, CASP8, CASP9, GSDME(DFNA5), ELANE, GSDMB, GSDMD, IL-1B, IL-6, IL-18, NLRC4, NLRP1, NLRP6, NLRP7, NOD1, PLCG1, PRKACA, PYCARD, and TIRAP) were identified between the HNSCC tissue and normal tissue. The gene discussed is CASP8; the disease is head and neck squamous cell carcinoma.