Higher expression of AIM2, CASP1, CASP5, CASP6, CASP8, GSDME (DFNA5), GSDMB, GSDMD, IL-18, IL6, NLRC4, NLRP6, NLRP7, NOD1, PLCG1, and PYCARD in HSNCC tissues compared with the normal tissues, whereas a few pyroptosis-related genes (CASP9, ELANE, IL-1B, NLRP1, TIRAP, and PRKACA) were downregulated in HNSCC tissues (P < 0.05) (Figure 1(b)). This evidence concerns the gene GSDME and head and neck squamous cell carcinoma.