Hence, the computational formula of prognostic-related risk score in HNSCC was as follows: risk score=(0.133 ∗ GSDME + 0.084 ∗ NOD1 + 0.039 ∗ IL6 + 0.003 ∗ IL1B + 0.084 ∗ CASP3 + 0.028 ∗ NLRP2). This evidence concerns the gene IL6 and head and neck squamous cell carcinoma.