IL33 and acute respiratory distress syndrome: For example, when IL-33 was transferred into Treg-depleted mice during the study of ARDS, Treg cell recovery and a significant increase in TGF-β1 secretion were observed, and lung regeneration was promoted by accelerating the recovery of AECII, presumably IL-33-dependent Tregs accumulation may accelerate lung epithelial regeneration in a TGF-β1-dependent manner (Tan et al., 2021).