Slc2a4, Adipoq, mitoNEET, and Tnmd transgenic mice had an equal or even higher degree of obesity than their littermates, but their metabolic profile is healthier (Shepherd et al., 1993; Kim et al., 2007; Kusminski et al., 2012; Senol-Cosar et al., 2016). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.