ADIPOQ and obesity due to melanocortin 4 receptor deficiency: During obesity, dysfunctional WAT is accompanied by a shift in adipokines secretion profile, which typically shows a reduction in anti-inflammatory factors such as adiponectin and interleukin-10 (IL-10), while an elevation in pro-inflammatory cytokines such as TNFα, interleukin- 1β (IL-1β), IL-6 and IL-18.