TNMD and obesity due to melanocortin 4 receptor deficiency: Slc2a4, Adipoq, mitoNEET, and Tnmd transgenic mice had an equal or even higher degree of obesity than their littermates, but their metabolic profile is healthier (Shepherd et al., 1993; Kim et al., 2007; Kusminski et al., 2012; Senol-Cosar et al., 2016).