Building a global population genetic picture of CYP2D6 variation and how it relates to safety and effectiveness of 8AQ treatment is critical due to the potentially large hypnozoite reservoir in malaria, but also because these drugs can also play a role in limiting P. falciparum transmission through gametocytocidal activity (Single low dose PQ (0.25 mg/kg) blocks P. falciparum gametocyte transmission without adverse reactions in G6PDd individuals (Bancone et al., 2016)). This evidence concerns the gene CYP2D6 and malaria.