SIRT1 and idiopathic pulmonary fibrosis: We evaluated SIRT1 secretion in the supernatant that was collected after the isolation and culture of PBMCs in media with the addition of human serum 10% ("serum supernatant"), and we did not find a statistically important difference between the two groups (19.6±3.3 ng/ml in IPF versus 14.8±1.2 ng/ml in controls, p=0.34, Figure 1B).