Long non-coding RNAs, SIRT1 antisense (SIRT1AS AS) expression is significantly decreased in bleomycin-induced pulmonary fibrosis, whereas SIRT1AS effectively inhibits TGF-β1-mediated epithelial-mesenchymal transition (EMT) in vitro and alleviates the progression of IPF in vivo [17]. This evidence concerns the gene SIRT1 and idiopathic pulmonary fibrosis.