Anecdotal reports suggested that, in presence of hyperglycemia, the expression of TACE is increased, which favors the shedding of ACE2, and its re-distribution to the lungs [81], possibly avoided with TACE suppression, which was claimed to improve the obesity-induced insulin resistance state as mice models would suggest [82]. This evidence concerns the gene ACE2 and obesity due to melanocortin 4 receptor deficiency.