The evidence and data from animal, basic science, epidemiological and clinical studies highlight the pleiotropic properties and benefits of GLP-1 RAs in reducing airway inflammation, pathological remodeling, and other pathobiological mechanisms underpinning asthma - beyond the well-known GLP-1 RA roles in treating diabetes and obesity. This evidence concerns the gene GCG and obesity due to melanocortin 4 receptor deficiency.