There is an urgent need for large randomized, controlled, clinically comparative trials of different GLP-1 RAs in the setting of co-occurring asthma, diabetes, and/or obesity. In sum, we recommend that all clinicians (MDs, NPs, and PA) strongly consider the use of GLP-1 RAs in the early stage of asthma in obese diabetics to prevent or slow down the beginning of pathological remodeling and permanent lung damage. Here, GLP1R is linked to obesity due to melanocortin 4 receptor deficiency.