At last, according to the significant role of the FGF21 gene in metabolic associated diseases and behavioral habits related to these diseases and additionally the direct influence of FGF21 variations on MAFLDs as well as the heritability pattern of fatty liver diseases (57, 58), there should be further studies for investigating the association of FGF21 genetic variations and MAFLDs. Here, FGF21 is linked to fatty liver disease.