FGF21 and obesity due to melanocortin 4 receptor deficiency: Previous studies also showed the importance of FGF21 genetic variations in obesity (rs11665896) (50), fat and macronutrient intake (rs838147) (51), renal function in diabetic patients (rs2071699, rs838136, and rs499765) (52), and alcohol dependence (rs11665896) (53) which indirectly can have effects on steatosis of liver.