In Chinese diabetes guidelines (9), metformin is the first-line hypoglycemic agent for patients with type 2 diabetes, and sulphonylurea (SU), glinides, α-glucosidase inhibitor (AGI), thiazolidinediones (TZDs), DPP-4i, sodium-glucose co-transporter 2 inhibitors (SGLT2i), GLP-1RA, and insulin are the main combination agents. The gene discussed is INS; the disease is diabetes mellitus.