A three-dimensional analysis of immune pattern of NAFLD-related HCC shows that a CD8+ > CD4+, Th1 > Th17 > Th2 pattern is related with tumor progression, while an equilibrium Th1 = Th17 = Th2 pattern in female and a semi-equilibrium Th1 = Th17 > Th2 pattern are associated with remission from HCC (111). Here, CD4 is linked to hepatocellular carcinoma.