CD8+ tissue-resident memory T (Trm) cells, maintained by tissue IL-15, can recruit HSCs in a CCR5-dependent manner and further result in FasL-Fas-mediated apoptosis of activated HSCs which can alleviate and delay the exacerbation of liver fibrosis in mice with NASH (121). The gene discussed is FASLG; the disease is metabolic dysfunction-associated steatohepatitis.