CD8A and metabolic dysfunction-associated steatohepatitis: When treated with metabolic stimuli (including acetate and extracellular ATP), CXCR6+ CD8+ T cells function as auto-aggressive cells in a way independent of MHC-class-I, which is induced by increased calcium influx and leads to the upregulation of FasL and apoptosis of hepatocytes thus promoting NASH (122–124).