Obesity-related oxidative stress leads to the recruitment of T cells accompanying NASH, fibrosis along with HCC through inactivation of STAT-1 and STAT-3 phosphatase T cell protein tyrosine phosphatase (TCPTP) and activation of STAT-1 and STAT-3 signaling (31). The gene discussed is PTPN2; the disease is obesity due to melanocortin 4 receptor deficiency.