In Caucasians, the average frequency of EGFR mutation in metastatic brain tumors from NSCLC is 6.2% (24/390) (1.6% in 19del and 3.7% in L858R) (Table 1) (32–36), which is lower than the EGFR mutation rate reported previously among the non-Asian origin (46, 47). This evidence concerns the gene EGFR and non-small cell lung carcinoma.