demonstrated that Notch and NF-κB signaling can increase miR-223 gene expression, which in turn downregulates the expression of the onco-suppressor FBW7, known to negatively regulate Notch signaling, thus suggesting that the Notch/miR-223/FBW7 axis may reinforce Notch signaling effect in T-ALL. This evidence concerns the gene NFKB1 and acute lymphoblastic leukemia.