The levels of CDKN1A, FOS, MCL1, and HMOX1 were high in CRC tissue and low in normal colorectal tissue, while those of CCND1, CDK1, MYC, PLAU, MET, and MMP3 were significantly higher in CRC tissues than in normal colorectal tissue. Here, CDKN1A is linked to colorectal carcinoma.