The aim of the present study was to systematically review the prognostic and therapeutic value of PLK-1 in different malignant neoplasms.<h4>Methods</h4>A systematic literature search of the Cochrane Library, PubMed, Web of Science, and China National Knowledge Internet (CNKI) databases was conducted between December 2018 and September 2022. The gene discussed is PLK1; the disease is cancer.