CD274 and gastric cancer: Refer to the HDAC6 selective inhibitors in clinical trials for solid tumor treatment, the extension experiment of canagliflozin may be carried out on metastatic or advanced gastric cancer by using alone or in combination with immunotherapy such as PD-1/PD-L1 antibody Nivolumab or chemotherapy such as Paclitaxel to explore the application of canagliflozin (33, 34).