Important vascular stimulators have been studied in HCC, including vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR), platelet-derived growth factor (PDGF)/platelet-derived growth factor receptor (PDGFR), endoglin (CD105), and angioportin/tie (17). This evidence concerns the gene ENG and hepatocellular carcinoma.