MRC1 and colorectal carcinoma: Therefore, we performed three IT injections (days 0, 7, and 14) of 50 μL of phosphate-buffered saline (PBS; PBS control groups) or low doses of MMR (1 × 102 TCID50 for each virus; MMR groups) into two subcutaneous mouse models of HCC (Hepa 1-6) and CRC (MC38) (Figure 1B).