While downregulation of the dynein cytoplasmic 1 heavy chain (Dync1h1), an essential member of the intracellular transport of DNA damage proteins family, has been linked to poor prognosis and low survival in glioblastoma (86), its upregulation was shown to delay tumor proliferation in gastrointestinal tumor cells (87). The gene discussed is DYNC1H1; the disease is glioblastoma.