While OLs numbers do not seem to be altered at 12 weeks in Pcp2-ATXN1[82Q] cerebellum, we have found increased expression of OL marker genes and neurosupportive genes including Trf, Mog, Cldn11, Rtn4, Glul, Cryab and ApoE. These results indicate neuroprotective effects of reactive cerebellar OLs in SCA1. Here, RTN4 is linked to spinocerebellar ataxia type 1.