CD83 and neoplasm: Consistent with this, NSCLC tissues expressing high GM3 (Neu5Gc) have a decrease amount of mature CD83+ DC cells [82, 83]; (iii) anti-Neu5Gc IgG Abs play an important role in tumor immune surveillance, being able to kill tumor cells which express GM3 (Neu5Gc) using complement, and also by a complement-independent oncotic necrosis mechanism.