In this study, ADGRD1 was significantly linearly correlated with 149 immune-related genes in NSCLC, and for GO functional annotation analysis, these genes were most enriched in terms “positive regulation of leukocyte activation”, “positive regulation of cell activation” , and “leukocyte migration” in BP category, “external side of plasma membrane”, “secretory granule lumen”, and “cytoplasmic vesicle lumen” in CC category, and “receptor ligand activity”, “cytokine activity”, and “cytokine receptor binding” in MF category. Here, ADGRD1 is linked to non-small cell lung carcinoma.