Proteinuria, creatinine increased, alanine aminotransferase increased, aspartate aminotransferase increased, abdominal pain, constipation, diarrhea, nausea, vomit, stomatitis, dysphonia, dyspnea, anemia, leukopenia, thrombocytopenia, neutropenia, hypertension. The gene discussed is GPT; the disease is hypertensive disorder.