It has been found that exosome miR‐1246 isolated from cerebrospinal fluid, plasma and cells of patients with glioma promotesthe differentiation of bone marrow‐derived inhibitory cells (MDSCs) by activating the dual specificity protein phosphatase 3 (DUSP3)/ERK signalling pathway, while hypoxia can induce the transcription of exosomal miR‐1246 and promote the activation of MDSCs. The gene discussed is DUSP3; the disease is central nervous system cancer.