It was found that circ‐SHPRH (SNF2 histone linker PHD RING helicase) was downregulated in GBM but highly expressed in normal human brain, and SHPRH‐146AA increased the ability of SHPRH to ubiquitinate PCNA by protecting SHPRF from ubiquitin proteasome degradation, resulting in decreased tumour proliferation and reduced tumour‐genic ability.132. The gene discussed is PCNA; the disease is glioblastoma.