The metalloproteinase integrin ADAM metallopeptidase domain 8 can act on the STAT3 and MAPK signalling pathways to regulate the expression of MMP9, CAMP responsive element binding protein 1, MEK1 and ERK2, thus regulating the level of miR‐181a‐5p and promoting the invasiveness of GBM.50 The gene discussed is STAT3; the disease is glioblastoma.