AKT3‐174aa encoded by circAKT3 negatively regulates the PI3K/AKT signalling pathway by interacting with phosphorylated pyruvate dehydrogenase kinase 1 (PDK1) in GBM; thus, the proliferation, radiation resistance and tumorigenic ability of GBM cells could be inhibited, which would provide benefits for the long‐term prognosis of patients.133. This evidence concerns the gene AKT1 and glioblastoma.