In addition, upregulation of lncRNA UCA1 contributes to temozolomide resistance in GBM, while silencing urothelial cancer associated 1 (UCA1) attenuates temozolomide resistance in GBM cells by inhibiting O‐6‐methylguanine‐DNA methyltransferase (MGMT) protein levels.97 This evidence concerns the gene MGMT and glioblastoma.