In addition, Wang et al.101proposed that GBM serum EV‐derived lncRNA HOTAIR (HOX transcript antisense RNA) could induce the proliferation, invasion and temozolomide resistance of GBM cells, and its malignant characteristics were mainly induced by the upregulation of epithelial V‐like antigen 1 (EVA1) expression via sponging miR‐526b‐3p. The gene discussed is MPZL2; the disease is glioblastoma.