Among all the 28 lncRNAs, only H19, HCG18, NUTM2A‐AS1, NR2F1‐AS1, HOXA11‐AS, PRKCQ‐AS1, SLC16A1‐AS1, and AC005519.1 were significantly upregulated, and AL158206.1, HIPK1‐AS1, VASH1‐AS1, AC004812.2 were downregulated in PC. This evidence concerns the gene SLC16A1 and pachyonychia congenita.