Among all the 28 lncRNAs, only H19, HCG18, NUTM2A‐AS1, NR2F1‐AS1, HOXA11‐AS, PRKCQ‐AS1, SLC16A1‐AS1, and AC005519.1 were significantly upregulated, and AL158206.1, HIPK1‐AS1, VASH1‐AS1, AC004812.2 were downregulated in PC. The gene discussed is NUTM2A; the disease is pachyonychia congenita.