The analysis of urine cells from pre-ESKD ADPKD patients revealed a moderately strong correlation between the urine CD206+ resident macrophage-like cell index and the average annual glomerular filtration rate (eGFR) decline over 5 years (r=0.474, P=0.008; Fig. 8B). The gene discussed is MRC1; the disease is autosomal dominant polycystic kidney disease.